Data & Sample Repository
The URBAN ARCH Consortium data and sample repository includes data and samples from a number of studies examining HIV and substance use. To request use of URBAN ARCH data or samples, please contact Natalia Gnatienko.
Click to access PDF versions of study assessment table of contents and available lab data.
| ENROLLMENT STATUS | INSTRUMENTS & FORMS* | BIOLOGICAL SAMPLES | ||
| Baseline | Follow Up | |||
UGANDA |
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| Uganda ARCH Cohort A prospective cohort study of 447 people with HIV, not on ART, to examine the effect of heavy alcohol consumption on HIV disease progression prior to ART. | COMPLETE | Plasma, Dried blood spots | ||
| BREATH A prospective cohort study of 212 people with HIV who consume alcohol to quantify changes in alcohol consumption during the first year of HIV care. | COMPLETE | Plasma | ||
| ADEPTT A single-arm trial of TB preventive therapy to assess its toxicity, measure adherence, and determine whether its benefits outweigh its risks when given to people with HIV co-infected with TB, who drink alcohol (n=300). | COMPLETE | N/A | ||
| TRAC The study will reenroll 500 prior study participants, who tested TST negative, and screen them for new TB infection to assess alcohol use through self-report and biomarkers, among people with HIV (PWH) and new TB infection in Uganda. | COMPLETE | Dried blood spots | ||
| TALC An 18-month observational study of 200 people living with HIV (PWLH) completing pulmonary TB treatment in Mbarara, Uganda. | ENROLLING | Dried blood spots | ||
| GRAIL A randomized, double-blinded, placebo-controlled trial that will evaluate the efficacy of gabapentin in promoting HVL suppression via reducing alcohol use among PWH, who are not virally suppressed. | ENROLLING | Dried blood spots | ||
RUSSIA |
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| Russia ARCH Cohort A prospective cohort study of 351 ART-naïve people with HVI to assess the relationship between alcohol consumption and biomarker concentrations. Click here for additional information about the Russia Cohort and here to see baseline characteristics. | COMPLETE | Serum and plasma, Dried blood spots | ||
| ZINC HIV A double-blinded randomized controlled trial to assess the efficacy of zinc supplementation vs. placebo among 254 people with HIV from the Russia ARCH Cohort, who are ART-naive at enrollment and have a recent history of heavy drinking. Click here for more information about ZINC HIV RCT. | COMPLETE | Serum and plasma, Dried blood spots | ||
| HERMITAGE A randomized controlled trial of 700 patients with HIV and risky alcohol consumption to test the effectiveness of a US HIV secondary prevention program, Healthy Relationships Intervention. | COMPLETE | N/A | ||
| IMPACT A cross-sectional study of 100 Russian people with HIV from the HERMITAGE cohort to investigate the relationship between substance use and HIV disease progression. | COMPLETE | N/A | Plasma, PBMC | |
| PREVENT A randomized controlled trial of 180 patients with alcohol and substance use disorder in substance use disorder treatment to develop and test the feasibility of adapting and implementing an efficacious US HIV prevention intervention in a Russian substance use disorder treatment center. | COMPLETE | N/A | ||
| LINC A randomized control trial of 349 Russian people with HIV who inject drugs to improve upon the treat and retain dimensions of the “seek, test, treat, and retain” paradigm in Russia. | COMPLETE | N/A | ||
| St PETER A 4-arm placebo-controlled randomized controlled trial (RCT) among 400 people with HIV with heavy drinking and smoking to compare the effects of varenicline, cytisine, and nicotine replacement therapy (NRT) to reduce: 1) alcohol use and craving, 2) smoking; and 3) inflammation and risk for CHD and mortality. | COMPLETE | Serum and plasma, Dried blood spots | ||
| SCRIPT A randomized, 2-arm pilot study, to support people with HIV who inject drugs (PWID) coping with dual internalized stigma related to HIV and substance use, to compare Acceptance and Commitment Therapy (ACT) with standard of care. | COMPLETE | N/A | ||
| LINC-II A two-armed randomized controlled trail among 225 people with HIV who inject drugs to implement and evaluate a multi-faceted intervention combining pharmacological therapy (i.e., rapid access to ART and receipt of naltrexone for opioid use disorder) and 12 months of strengths-based case management. | COMPLETE | N/A | ||
| HIV Latency Study A study to address how opioid use alters the immune response in HIV patients and to develop a method to assess HIV latency among people who use opioids | COMPLETE | N/A | N/A | PBMC, Plasma |
| ACME A study nested within the St PETER HIV trial to determine if changes in the gut microbiome are associated with heavy alcohol use; to determine the effect of dysbiosis on intestinal permeability, microbial translocation, inflammation, and trimethylamine N-oxide (TMAO) levels; and if changes in the bacteria of the gut are associated with changes in cardiac structure and function. | COMPLETE | Fecal, Nasal, Dried blood spots, Blood | ||
| TMAO A study nested within the St PETER HIV trial to assess whether heavier alcohol use is associated with increased trimethylamine N-oxide (TMAO), and subsequently whether increased TMAO levels are associated with subclinical measures and biomarkers of heart failure. | COMPLETE | Fecal | ||
| PETER Pain UH2 A pilot study to assess the feasibility, tolerability, and safety of using low-dose naltrexone and standard dose nalmefene to treat pain among people with HIV with alcohol use and chronic pain. | COMPLETE | N/A | ||
| PETER Pain UH3 A pilot study to compare effects of low-dose naltrexone and gabapentin to placebo among people with HIV with heavy alcohol use and chronic pain. | COMPLETE | N/A | ||
UNITED STATES |
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| Boston ARCH Cohort A prospective cohort study of 250 people with HIV affected by multiple substances-a spectrum of alcohol use, and all with substance use disorder or Injection drug use. Click here for additional information about the Boston Cohort. Click here to see baseline characteristics. | COMPLETE | Serum and plasma, Dried blood spots | ||
| FAST PATH A SAMHSA-funded clinical program of 450 patients with alcohol or drug dependence who are at high-risk for transmitting or contracting HIV through risky drug or sexual behaviors to provide substance use disorder treatment in conjunction with medical care and HIV prevention and risk reduction counseling in primary care settings. | COMPLETE | N/A | ||
| HIV-LIVE A prospective cohort study of 400 patients with HIV with a history of alcohol problems to investigate the relationship between alcohol and HIV progression and related factors in the context of the additional exposure of HCV infection. | COMPLETE | Serum | ||
| 4F A prospective cohort study of 400 people with HIV with a high prevalence of exposure to alcohol, illicit drugs, and polypharmacy to 1) test the associations between alcohol (and illicit drugs and polypharmacy) and falls (fractures secondarily), and 2) test the associations between alcohol (and illicit drugs and polypharmacy) and acute healthcare utilization. | COMPLETE | N/A | ||
| Internet-based Video-Conferencing UH2 An intervention development and preliminary testing project involving feedback from experts, qualitative interviews, test cases, and an open trial conducted with 8 heavy drinking HIV-positive patients. This UH2 seeks to develop a novel, integrated behavioral approach to reduce heavy drinking and chronic pain among patients in HIV care delivered via internet-based videoconferencing. | COMPLETE | N/A | ||
| Internet-based Video-Conferencing UH3 A randomized controlled pilot trial to compare a novel integrated behavioral video telehealth intervention for heavy drinking people with HIV with chronic pain to a control condition. | COMPLETE | N/A | ||
OTHER |
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| TAJ STUDY A cross-sectional study of 500 men with HIV who purchase sex and among women with HIV who sell sex recruited from Mumbai and Guntur to enable development of intervention research to address alcohol-related risky sex and, ultimately, reduce the transmission of HIV in India. | COMPLETE | N/A | N/A | |